USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: EPS15_HUMAN USC-OGP 2-DE database:  EPS15_HUMAN EPS15_HUMAN General information about the entry View entry in simple text format Entry name EPS15_HUMAN Primary accession number P42566 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Epidermal growth factor receptor substrate 15; Short=Protein Eps15; AltName: Full=Protein AF-1p;. Gene name Name=EPS15 Synonyms=AF1P Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0048: pI=4.78; Mw=56395 SPOT OGP-0051: pI=4.80; Mw=55653 Cross-references UniProtKB/Swiss-Prot P42566; EPS15_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name EPS15_HUMAN Primary accession number P42566 Secondary accession number(s) B2R8J7 D3DPJ2 Q5SRH4 Sequence was last modified on  June 7, 2005 (version 2) Annotations were last modified on  March 15, 2017 (version 186) Name and origin of the protein Description RecName: Full=Epidermal growth factor receptor substrate 15; Short=Protein Eps15; AltName: Full=Protein AF-1p; Gene name Name=EPS15 Synonyms=AF1P Encoded on Name=EPS15; Synonyms=AF1P Keywords 3D-structure; Acetylation; Alternative splicing; Calcium; Cell membrane; Chromosomal rearrangement; Coated pit; Complete proteome; Cytoplasm; Endocytosis; Endosome; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Protein transport; Proto-oncogene; Reference proteome; Repeat; SH3-binding; Transport; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U07707; AAA52101.1; -; mRNA EMBL Z29064; CAA82305.1; -; mRNA EMBL AK313396; BAG36194.1; -; mRNA EMBL DQ367924; ABD34786.1; -; mRNA EMBL BX647676; -; NOT_ANNOTATED_CDS; mRNA EMBL AL671986; CAI13030.1; -; Genomic_DNA EMBL AC104170; CAI13030.1; JOINED; Genomic_DNA EMBL CH471059; EAX06823.1; -; Genomic_DNA CCDS CCDS557.1; -. [P42566-1]; . PIR S43074; S43074; . RefSeq NP_001153441.1; NM_001159969.1. [P42566-2]; . RefSeq NP_001972.1; NM_001981.2. [P42566-1]; . UniGene Hs.83722; -; . PDB 1C07; NMR; -; A=217-311 PDB 1EH2; NMR; -; A=121-218 PDB 1F8H; NMR; -; A=121-215 PDB 1FF1; NMR; -; A=121-215 PDB 2IV9; X-ray; 1.90 A; P=723-730 PDB 2JXC; NMR; -; A=121-215 PDB 4RH5; X-ray; 1.60 A; B=846-854 PDB 4RH9; X-ray; 1.60 A; B=846-854 PDB 4RHG; X-ray; 1.58 A; B=846-854 PDB 4S0G; X-ray; 1.72 A; B=846-854 PDB 5AWT; X-ray; 2.70 A; B=640-649 PDB 5AWU; X-ray; 2.70 A; B=645-654 PDB 5JP2; X-ray; 2.40 A; E/F=615-637 PDBsum 1C07; -; . PDBsum 1EH2; -; . PDBsum 1F8H; -; . PDBsum 1FF1; -; . PDBsum 2IV9; -; . PDBsum 2JXC; -; . PDBsum 4RH5; -; . PDBsum 4RH9; -; . PDBsum 4RHG; -; . PDBsum 4S0G; -; . PDBsum 5AWT; -; . PDBsum 5AWU; -; . PDBsum 5JP2; -; . ProteinModelPortal P42566; -; . SMR P42566; -; . BioGrid 108374; 153; . DIP DIP-33064N; -; . IntAct P42566; 73; . MINT MINT-107223; -; . STRING 9606.ENSP00000360798; -; . iPTMnet P42566; -; . PhosphoSitePlus P42566; -; . BioMuta EPS15; -; . DMDM 67476728; -; . OGP P42566; -; . EPD P42566; -; . MaxQB P42566; -; . PaxDb P42566; -; . PeptideAtlas P42566; -; . PRIDE P42566; -; . Ensembl ENST00000371733; ENSP00000360798; ENSG00000085832. [P42566-1]; . GeneID 2060; -; . KEGG hsa:2060; -; . UCSC uc001csq.2; human. [P42566-1]; . CTD 2060; -; . DisGeNET 2060; -; . GeneCards EPS15; -; . HGNC HGNC:3419; EPS15; . HPA CAB010164; -; . HPA HPA008451; -; . MIM 600051; gene; . neXtProt NX_P42566; -; . OpenTargets ENSG00000085832; -; . PharmGKB PA27838; -; . eggNOG KOG0998; Eukaryota; . eggNOG ENOG410XTDR; LUCA; . GeneTree ENSGT00760000118985; -; . HOGENOM HOG000004804; -; . HOVERGEN HBG005591; -; . InParanoid P42566; -; . KO K12472; -; . OMA HAEGQGN; -; . OrthoDB EOG091G01RG; -; . PhylomeDB P42566; -; . TreeFam TF324293; -; . Reactome R-HSA-182971; EGFR downregulation; . Reactome R-HSA-6807004; Negative regulation of MET activity; . Reactome R-HSA-8856825; Cargo recognition for clathrin-mediated endocytosis; . Reactome R-HSA-8856828; Clathrin-mediated endocytosis; . Reactome R-HSA-8875360; InlB-mediated entry of Listeria monocytogenes into host cell; . SignaLink P42566; -; . SIGNOR P42566; -; . ChiTaRS EPS15; human; . EvolutionaryTrace P42566; -; . GeneWiki EPS15; -; . GenomeRNAi 2060; -; . PRO PR:P42566; -; . Proteomes UP000005640; Chromosome 1; . Bgee ENSG00000085832; -; . CleanEx HS_EPS15; -; . ExpressionAtlas P42566; baseline and differential; . Genevisible P42566; HS; . GO GO:0016235; C:aggresome; IDA:UniProtKB; . GO GO:0030122; C:AP-2 adaptor complex; IEA:Ensembl; . GO GO:0016324; C:apical plasma membrane; IEA:Ensembl; . GO GO:0009925; C:basal plasma membrane; IEA:Ensembl; . GO GO:0060170; C:ciliary membrane; IEA:Ensembl; . GO GO:0005905; C:clathrin-coated pit; TAS:UniProtKB; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell; . GO GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; IDA:HGNC; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0005509; F:calcium ion binding; IEA:InterPro; . GO GO:0031593; F:polyubiquitin binding; IDA:UniProtKB; . GO GO:0008283; P:cell proliferation; TAS:ProtInc; . GO GO:0048268; P:clathrin coat assembly; IDA:BHF-UCL; . GO GO:0032456; P:endocytic recycling; IC:BHF-UCL; . GO GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:ProtInc; . GO GO:0006895; P:Golgi to endosome transport; IMP:UniProtKB; . GO GO:0061024; P:membrane organization; TAS:Reactome; . GO GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome; . GO GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl; . GO GO:0015031; P:protein transport; IEA:UniProtKB-KW; . GO GO:0019065; P:receptor-mediated endocytosis of virus by host cell; IMP:CACAO; . GO GO:0042127; P:regulation of cell proliferation; IEA:Ensembl; . GO GO:0016050; P:vesicle organization; TAS:UniProtKB; . GO GO:0046718; P:viral entry into host cell; IMP:CACAO; . Gene3D 1.10.238.10; -; 3; . InterPro IPR011992; EF-hand-dom_pair; . InterPro IPR018247; EF_Hand_1_Ca_BS; . InterPro IPR002048; EF_hand_dom; . InterPro IPR000261; EH_dom; . InterPro IPR003903; UIM_dom; . Pfam PF12763; EF-hand_4; 3; . SMART SM00054; EFh; 3; . SMART SM00027; EH; 3; . SMART SM00726; UIM; 3; . SUPFAM SSF47473; SSF47473; 3; . PROSITE PS00018; EF_HAND_1; 2; . PROSITE PS50222; EF_HAND_2; 4; . PROSITE PS50031; EH; 3; . PROSITE PS50330; UIM; 2; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
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• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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